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January 12, 2001Science

Disruption of PD-1 in BALB/c mice caused dilated cardiomyopathy with severely impaired contraction and sudden death by congestive heart failure, associated with diffuse IgG deposition and high-titer circulating IgG autoantibodies.

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Population

BALB/c mice and BALB/c RAG-2-/- mice

Comparison

Disruption of the gene encoding the negative… vs BALB/c RAG-2-/- mice

Design

Preclinical

Authors

HNHiroyuki NishimuraTOTaku OkazakiYTYoshimasa Tanaka

Discussion

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Overview

Alerts to possible cardiotoxicity of PD-1 inhibitors; leaves open translation to human autoimmune cardiomyopathy.

Structured PICO

P
Population
BALB/c mice and BALB/c RAG-2-/- mice
I
Intervention
Disruption of the gene encoding the negative immunoregulatory receptor PD-1
C
Comparator
BALB/c RAG-2-/- mice
O
Outcome
Development of dilated cardiomyopathy, impaired contraction, and sudden death by congestive heart failure

PD-1 deficiency in mice leads to autoimmune dilated cardiomyopathy, suggesting PD-1 is a crucial factor in preventing autoimmune heart disease.

Cite This Study

Nishimura et al. (2001) studied this question.

synapsesocial.com/papers/69dd53b0fb7610310c10223ehttps://doi.org/10.1126/science.291.5502.319
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.1978 · 7,489 citations
  2. 2Antibodies to the ADP/ATP carrier, an autoantigen in myocarditis and dilated cardiomyopathy, penetrate into myocardial cells and disturb energy metabolism in vivo.1989 · 138 citations
  3. 3Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy2000 · 75 citations
  4. 4Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses1998 · 495 citations