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August 2, 2018Diabetes Care133 citationsOpen Access

Sex and BMI Alter the Benefits and Risks of Sulfonylureas and Thiazolidinediones in Type 2 Diabetes: A Framework for Evaluating Stratification Using Routine Clinical and Individual Trial Data

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JDJohn DennisWHWilliam HenleyMWMichael N. Weedon

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Abstract

Patient subgroups defined by sex and BMI have different patterns of benefits and risks on thiazolidinedione and sulfonylurea therapy. Subgroup-specific estimates can inform discussion about the choice of therapy after metformin for an individual patient. Our approach using routine and shared trial data provides a framework for future stratification research in type 2 diabetes.

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Dennis et al. (2018) studied this question.

synapsesocial.com/papers/69dd5f0c3f27c4971e99b5b6https://doi.org/10.2337/dc18-0344
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