RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons

Key Points

• The study aims to investigate how MBNL2 contributes to alleviating neuropathic pain following chemotherapy by affecting CCR2 expression.
• Analyzed MBNL2 expression in primary sensory neurons after chemotherapy
• Examined the effects on CCR2 expression and its relation to neuropathic pain
• Utilized paclitaxel to induce neuropathic pain model
• Increased MBNL2 expression correlates with decreased CCR2 levels in primary sensory neurons
• Reduced neuropathic pain symptoms in models with elevated MBNL2 following chemotherapy
• Established a link between MBNL2 activity and pain modulation mechanisms.