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April 14, 2026Journal of Obstetrics Gynecology and Cancer Research0 citationsOpen Access

Single-Dose vs. Triple- dose Antibiotic Prophylaxis in Preventing Postoperative Infection in Elective Cesarean Section: A Randomized Controlled Trial

SMShohre MovahediZGZahra GhalenoeeMMMohammad Mirzaei

Key Points

  • The study aims to compare the effectiveness of single-dose versus triple-dose antibiotic prophylaxis in preventing postoperative infections after elective cesarean sections.
  • Double-blinded randomized clinical trial design
  • Participants: 120 pregnant women undergoing elective cesarean sections
  • Group 1: 2g Cefazolin as a single dose before surgery
  • Group 2: Cefazolin administered as single dose pre-surgery plus two doses post-surgery
  • Postoperative infection monitored at one week, two weeks, and one month post-operation
  • No statistically significant difference in cellulitis incidence (5% vs. 1.7%, P=0.238)
  • Adhesion rates were similar between groups (1.7% vs. 3.3%, P=0.559)
  • Purulent discharge occurred in 3.3% of one group compared to none in the other (P=0.238)
  • No cases of urine infection or postoperative fever reported in either group

Abstract

Background P=0.238), adhesion (1.7% vs. 3.3%, P=0.559, purulent discharge (3.3% vs 0%, P=0238) . No cases of urine infection and postoperative fever were reported in any of the two groups.Conclusion: Single-dose antibiotic prophylaxis using cefazolin has comparable efficacy to multi-dose antibiotic regimens and potentially offers a cost-effective advantage.

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Cite This Study

Movahedi et al. (2026) studied this question.

synapsesocial.com/papers/69ddd959e195c95cdefd6a4dhttps://doi.org/10.24200/jogcr.11.5.428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of single versus multiple doses of antibiotics in elective cesarean section for prevention of post operative morbidity2024
  2. 2Randomized controlled trial of cefazolin monotherapy versus cefazolin plus azithromycin single dose prophylaxis for cesarean deliveries2019 · 29 citations
  3. 3The study of single dose antibiotic in caesarean section2020
  4. 4A Retrospective Exploration of Pre-operative Antibiotic Prophylaxis with Cefazolin in Cesarean Sections: Implications for Obstetrics and Gynecologic Surgery2024 · 4 citations
  5. 5Association between Timing of Prophylactic Antibiotic in Cesarean Section and Risk of Postpartum and Neonatal Infections2025