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April 14, 2026

Evaluation of CD19+ CD24+CD27 B cell and serum level of interleukin 10 and interleukin 35 in patients with systemic lupus erythematosus.

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Authors

NANashwa S. M. AbdeenRAReham M A AbdallaHAHeba M A Abdalla

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Overview

Evaluation studies find altered cytokine levels and B cell populations in systemic lupus erythematosus, indicating disease activity.

Key Points

  • This research aims to investigate the frequency of specific B cells and serum cytokines in patients with systemic lupus erythematosus.
  • Evaluated CD19+CD24highCD27+ B cell frequencies in 40 patients with systemic lupus erythematosus and compared to 25 controls.
  • Measured serum levels of interleukin-10 and interleukin-35.
  • Analyzed correlations between B cell counts and systemic lupus erythematosus disease activity index (SLEDAI) scores.
  • Active systemic lupus erythematosus patients showed significantly lower CD19+CD24highCD27+ B cell counts than controls.
  • Levels of interleukin-35 were significantly decreased in patients with active disease compared to those with inactive disease and controls.
  • Interleukin-10 levels were significantly higher in active patients than those inactive and controls.
  • There was a strong negative correlation between regulatory B cell counts and SLEDAI scores.

Cite This Study

Abdeen et al. (2026) studied this question.

synapsesocial.com/papers/69ddd959e195c95cdefd6aa5https://doi.org/10.55133/eji.330204
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