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April 14, 2026Diseases of the EsophagusOpen Access

Impact of a diagnosis of ‘low-grade dysplasia’ in patients with Barrett’s esophagus

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Authors

CKChih‐Han KungRVRavi VissapragadaASAnn Carolyn Schloithe

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Overview

This analysis reveals the progression risks of low-grade dysplasia in Barrett’s esophagus and cost-effective management strategies.

Key Points

  • The study aims to understand the implications of low-grade dysplasia (LGD) diagnosis in Barrett's esophagus and evaluate management strategies.
  • Retrospective analysis from a large single-center prospective Barrett's esophagus surveillance database.
  • Patients were divided into groups based on dysplasia status at surveillance entry and during surveillance.
  • Annual incidence rates of progression to high-grade dysplasia (HGD) or adenocarcinoma (EAC) were calculated per 100 person-years.
  • Total progression to HGD/EAC was 5.0% over the total surveillance time of 5212 person-years.
  • Progression rates were 0.6 for non-dysplastic BE, 1.0 for LGD at entry, and 2.2 for LGD during surveillance, with significant differences.
  • Radiofrequency ablation (RFA) was identified as the most cost-effective strategy for managing LGD detected during surveillance.

Cite This Study

Kung et al. (2026) studied this question.

synapsesocial.com/papers/69ddd9f9e195c95cdefd76d6https://doi.org/10.1093/dote/doag028
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