Ventricular Tachycardia Ablation Outcomes in Patients Without Previous Implantable Cardioverter-Defibrillator Insertion: A Propensity Score-matched Analysis.

Ventricular tachycardia (VT) is a fatal arrhythmia, often managed with implantable cardioverter-defibrillators (ICDs). Many patients, however, present without an ICD. The role of catheter ablation in this high-risk group is unclear, particularly for short-term in-hospital outcomes. We assessed associations between ablation and in-hospital outcomes among ICD-naive VT patients using a large national dataset. We conducted a retrospective study using the National Inpatient Sample (2016-2021), identifying adult hospitalizations with VT. Patients with prior ICDs or ICD implantation during the same admission were excluded. The cohort was divided into those who underwent catheter ablation versus those managed without ablation. Multivariable logistic regression and 1:1 propensity score matching (PSM) adjusted for demographic, clinical, and hospital factors. The primary outcome was in-hospital mortality; secondary outcomes included ST-elevation myocardial infarction (STEMI), sepsis, major adverse cardiac events (MACEs) (death, STEMI, or cardiogenic shock), cardiogenic shock, tamponade, mechanical circulatory support (MCS), acute heart failure, and prolonged hospitalization (≥7 days). Of 2,214,424 VT hospitalizations, 32,640 (1.5%) underwent catheter ablation. After PSM (n = 12,668), ablation was associated with significantly lower rates of in-hospital mortality (3.17% vs. 8.98%; P P P P P P P < .001). Rates of acute heart failure and prolonged hospitalization were comparable. In ICD-naive VT patients, catheter ablation was associated with improved in-hospital survival and fewer complications, albeit with higher procedural risks.