Dearomatization with Axial‐to‐Central Chirality Conversion

Aromatic atropisomers, that is to say aromatic compounds that exhibit chirality because of a hindered rotation around the bond linking them to one of their substituents, have recently received an increased interest, both as synthetic targets and as molecules of interest for applications as catalysts or in medicinal chemistry. However, despite the easier access to diversified enantioenriched aromatic atropisomers, considering them as substrates is not very frequent, notably in the context of dearomatization reactions. It is even more regrettable, as such transformations can deliver enantioenriched original motifs through an axial‐to‐central chirality conversion. The goal of this review is to provide a general overview of dearomative transformations of aromatic atropisomers to help the synthetic chemists community identifying new potential research directions in this subfield.