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March 21, 2007New England Journal of Medicine376 citationsOpen Access

Neurodevelopment and Cognition in Children after Enterovirus 71 Infection

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LCLuan‐Yin ChangLHLi‐Min HuangSGSusan Shur‐Fen Gau

Structured PICO

Does cardiopulmonary failure in children with Enterovirus 71 infection and CNS involvement affect neurodevelopment and cognitive functioning?

P
Population
Children after Enterovirus 71 infection
O
Outcome
Neurologic sequelae, delayed neurodevelopment, and reduced cognitive functioning

Children with Enterovirus 71 infection and CNS involvement who develop cardiopulmonary failure are at risk for delayed neurodevelopment and reduced cognitive functioning.

Abstract

Enterovirus 71 infection with CNS involvement and cardiopulmonary failure may be associated with neurologic sequelae, delayed neurodevelopment, and reduced cognitive functioning. Children with CNS involvement without cardiopulmonary failure did well on neurodevelopment tests. (ClinicalTrials.gov number, NCT00172393 ClinicalTrials.gov.).

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Cite This Study

Chang et al. (2007) studied this question.

synapsesocial.com/papers/69df6f04d5404a0bea5932d5https://doi.org/10.1056/nejmoa065954
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management2002 · 189 citations
  2. 2Adverse Outcomes of Bacterial Meningitis in School-Age Survivors1995 · 182 citations
  3. 3Clinical outcome and neurological sequelae in serologically confirmed cases of Japanese encephalitis patients in Assam, India.2002 · 35 citations
  4. 4Stability of the WAIS-R and WISC-III factor structure using cross-validation of covariance structures1995 · 25 citations
  5. 5Herpes simplex encephalitis: analysis of 68 cases from a tertiary care hospital in Karachi, Pakistan.2005 · 30 citations