Synthesis of Multisubstituted Diazatricyclic Molecules Via Intramolecular Cycloaddition of Cyclic Azomethine Ylides

Key Points

• To synthesize multisubstituted diazatricyclic molecules through intramolecular cycloaddition of azomethine ylides.
• Transformed 4-hydroxyproline derivative into amino group
• Introduced allyl substituent via cross-metathesis
• Condensed derivatives with aldehydes to create azomethine ylides
• Performed intramolecular cycloaddition to form tricyclic framework.
• Successfully synthesized diazatricyclic molecules with promising structural diversity
• Identified functional groups for further derivatization within the tricyclic framework.

Abstract