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April 16, 2026Hepatology CommunicationsOpen Access

Fracture risk under selective and non-selective PPAR agonists in primary biliary cholangitis

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Authors

UBU. BeuersARAlexandra RousseauSGStan F.J. van de Graaf

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Overview

Post hoc analysis finds varying fracture risks among PPAR agonists in PBC, indicating potential safety concerns.

Key Points

  • This analysis aims to evaluate the fracture risk associated with different PPAR agonists in patients with primary biliary cholangitis (PBC).
  • Post hoc analysis of randomized, placebo-controlled trials
  • Assessment of fracture incidence in PBC patients on selective and non-selective PPAR agonists
  • Comparison of serum vitamin D levels and deficiency rates across groups
  • Analysis of cumulative fractures over a 2-year treatment period
  • Seladelpar group reported 4.1 fractures per 100 person-years; no fractures in placebo group
  • Elafibranor group had up to 6.5 fractures per 100 person-years; none in placebo group
  • Bezafibrate showed similar fracture rates as placebo, with no significant difference reported.

Cite This Study

Beuers et al. (2026) studied this question.

synapsesocial.com/papers/69e07c1e2f7e8953b7cbd8e3https://doi.org/10.1097/hc9.0000000000000945
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reply: Fracture risk under selective and non-selective PPAR agonists in primary biliary cholangitis2026
  2. 2Effectiveness and tolerability of bezafibrate in primary biliary cholangitis – a nationwide real-world study2025 · 4 citations
  3. 3Letter: Therapeutic Targeting of <scp>PPARs</scp> in <scp>PBC</scp> —Additional Considerations2026 · 1 citations
  4. 4Peroxisome Proliferator-Activated Receptor Agonists in Primary Biliary Cholangitis and Other Liver Diseases: Mechanisms, Clinical Evidence, and Future Directions2026
  5. 5Increased risk of fragility fractures in patients with primary biliary cholangitis2024 · 1 citations