Microfluidic Co-Assembly of PEG/PEG- Lipid -Incorporated PBAE Nanoparticles for Enhanced Non-Viral Gene Delivery

Key Points

• This research aims to improve gene delivery systems for better clinical outcomes in gene therapy.
• Utilized microfluidics for co-assembly of nanoparticles
• Incorporated PEG and PEG-lipid into formulations
• Evaluated delivery efficiency and stability
• Nanoparticles showed enhanced gene delivery efficiency
• Improved stability was observed in gene therapy applications
• Demonstrated potential for better clinical translation of gene therapy

Abstract