Computational-based integrative methylome-transcriptome analysis reveals widespread enhancer hypomethylation in esophageal carcinoma

Key Points

• The research aims to explore enhancer hypomethylation in esophageal carcinoma and identify potential biomarkers.
• Conducted computational-based integrative analysis of methylome and transcriptome data.
• Focused on identifying hypomethylated enhancers associated with esophageal carcinoma.
• Evaluated the diagnostic and prognostic potential of candidate biomarkers LINC02547 and PYGL.
• Documented widespread enhancer hypomethylation as a characteristic of esophageal carcinoma.
• Identified LINC02547 and PYGL as promising biomarker candidates for further validation.

Abstract