A triglyceride-glucose index of ≥8.52 was independently associated with an increased risk of endothelial dysfunction (OR 1.27) compared to lower index values.
Cross-Sectional (n=5,961)
Yes
Does a high triglyceride-glucose index or elevated fasting blood glucose increase the risk of endothelial dysfunction?
A high triglyceride-glucose index (≥ 8.52) or fasting blood glucose ≥ 95 mg/dL is associated with a higher risk of endothelial dysfunction.
Effect estimate: OR 1.27 (95% CI 1.10-1.48)
We defined triglyceride-glucose (TyG) index < 8.52 as a low TyG index and TyG index ≥ 8.52 as a high TyG index, and divided the subjects into nine groups based on the levels of TyG index and fasting blood glucose (FBG) levels: FBG levels < 90 mg/dL and low TyG index, FBG levels < 90 mg/dL and high TyG index, FBG levels of 90–94 mg/dL and low TyG index, FBG levels of 90–94 mg/dL and high TyG index, FBG levels of 95–99 mg/dL and low TyG index, FBG levels of 95–99 mg/dL and high TyG index, FBG levels of 100–125 mg/dL and low TyG index, FBG levels of 100–125 mg/dL and high TyG index, and diabetes mellitus. The odds ratios for endothelial dysfunction were significantly higher in groups with high TyG index and any levels of FBG, and the group with low TyG index and FBG levels of 95–99 mg/dL, the group with low TyG index and FBG levels of 100–125 mg/dL and the diabetes mellitus group than the FBG levels < 90 mg/dL and low TyG index group. Even at a low TyG index, subjects with FBG levels ≥ 95 mg/dL might have a higher risk for endothelial dysfunction.
Yamaji et al. (Tue,) conducted a cross-sectional in Endothelial dysfunction (n=5,961). Triglyceride-glucose (TyG) index ≥8.52 vs. TyG index <8.52 was evaluated on Endothelial dysfunction (FMD <4.4%) (OR 1.27, 95% CI 1.10-1.48). A triglyceride-glucose index of ≥8.52 was independently associated with an increased risk of endothelial dysfunction (OR 1.27) compared to lower index values.