Construction of 2H-1,4-selenazin-3(4H)-one framework via cyclization of pyrazole derivatives bearing chloroacetamide and selenocyanate fragments

Key Points

• The aim is to synthesize a novel class of compounds, specifically substituted 1,7-dihydropyrazolo[4,3-b][1,4]selenazinones.
• Developed a three-step synthesis method.
• Started from readily available 5-aminopyrazoles.
• Utilized cyclization of pyrazole derivatives with chloroacetamide and selenocyanate.
• Successfully synthesized substituted 1,7-dihydropyrazolo[4,3-b][1,4]selenazin-6(5H)-ones.
• The method is efficient and can be applied to various pyrazole derivatives.

Abstract