PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 16, 2026Discover Oncology1 citationsOpen Access

Integrative multi-omics analysis identifies PAICS as a key regulator of epithelial-mesenchymal transition in breast cancer metastasis

JGJian GuoLCLichao CenXQXinye Qian

Key Points

  • The aim is to identify PAICS as a key regulator involved in the epithelial-mesenchymal transition linked to breast cancer metastasis.
  • Conducted multi-omics analysis to examine molecular interactions
  • Evaluated PAICS expression levels in breast cancer samples
  • Analyzed immune microenvironment changes related to PAICS activity
  • PAICS is identified as a significant biomarker for breast cancer metastasis
  • Modulation of epithelial-mesenchymal transition is linked to PAICS
  • Alterations in the immune microenvironment are associated with PAICS expression

Abstract

PAICS acts as a biomarker that promotes breast cancer metastasis by modulating epithelial-mesenchymal transition and the immune microenvironment, offering potential for clinical translation.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Guo et al. (2026) studied this question.

synapsesocial.com/papers/69e07dc72f7e8953b7cbeb3chttps://doi.org/10.1007/s12672-026-04968-4
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The cancer metabolic reprogramming and immune response2021 · 1,356 citations
  2. 2Bioinformatics analysis of the immune cell infiltration characteristics and correlation with crucial diagnostic markers in pulmonary arterial hypertension2023 · 14 citations
  3. 3Bevacizumab (Avastin®) in cancer treatment: A review of 15 years of clinical experience and future outlook2020 · 1,168 citations
  4. 4Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives2019 · 250 citations
  5. 5Cisplatin prevents breast cancer metastasis through blocking early EMT and retards cancer growth together with paclitaxel2020 · 146 citations