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April 16, 2026Nature Communications1 citationsOpen Access

Potent Acridone Antimalarial Targeting All Plasmodium Life Stages

Potent acridone antimalarial against all three life stages of Plasmodium

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Authors

PKPapireddy KancharlaRDRozalia A. DodeanYLYuexin Li

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Overview

Uncovers a potent acridone antimalarial that targets all Plasmodium stages, suggesting new treatment avenues.

Key Points

  • To evaluate the efficacy and safety of the acridone T111 against all life stages of Plasmodium.
  • In vitro testing against cultured parasites
  • Ex vivo testing against clinical isolates
  • Single-dose oral cure in a rodent model
  • Toxicology evaluations in rats
  • Resistance mechanism analysis in selected parasites
  • T111 exhibited potent activity against blood, liver, and mosquito stages
  • Effective single-dose cure in rodent models
  • Demonstrated synergy with tafenoquine
  • Safety profile shows low toxicity rates
  • Mechanism distinct from existing antimalarials targeting mitochondrial pathways

Cite This Study

Kancharla et al. (2026) studied this question.

synapsesocial.com/papers/69e07dc72f7e8953b7cbeb66https://doi.org/10.1038/s41467-026-71708-1
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