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Synapse
April 16, 2026Psychiatry and Clinical Neurosciences2 citations

Integrated transcriptomic and clinical analysis of autism spectrum disorder reveals structured heterogeneity and links Methyl‐CpG Binding Domain Protein 2 expression with symptom severity

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WYWasana YuwattanaChulalongkorn UniversityCPChayanit PoolcharoenChulalongkorn UniversityTSThanit SaeliwChulalongkorn University

Key Points

  • To investigate biological heterogeneity in autism spectrum disorder (ASD) through integrated transcriptomic and clinical analyses.
  • Conducted transcriptomic analyses to assess gene expression patterns in ASD
  • Stratified data to reveal molecular heterogeneity
  • Correlated symptoms severity with expression levels of specific proteins
  • Identified structured biological heterogeneity in ASD
  • Established a link between Methyl-CpG Binding Domain Protein 2 expression and the severity of symptoms

Abstract

Transcriptomic stratification reveals biologically structured heterogeneity in ASD that is only partially reflected in clinical presentation, supporting a multilayered framework integrating molecular and phenotypic dimensions.

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Cite This Study

Yuwattana et al. (2026) studied this question.

synapsesocial.com/papers/69e07dc72f7e8953b7cbeb8ehttps://doi.org/10.1111/pcn.70065
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