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April 16, 2026Biomaterials Science0 citations

Photothermal self-adjuvant porous microneedles for self-healing encapsulation and sustained release of antigens to improve adaptive immunity

XWXin WangZLZhiming LiJFJiahui Fu

Key Points

  • The aim is to enhance adaptive immunity through a novel microneedle system that releases antigens sustainably.
  • Development of photothermal self-adjuvant porous microneedles
  • Assessment of antigen encapsulation and release profiles
  • Evaluation of immune responses following application
  • Microneedles maintained antigen integrity and facilitated sustained release.
  • Enhanced adaptive immune responses were observed post-vaccination.
  • Demonstrated safe adjuvanticity without adverse effects.

Abstract

Effective vaccination hinges on overcoming persistent challenges in delivery site optimization, sustained antigen release, maintaining antigen integrity, and providing safe adjuvanticity. Here, we report a photothermal self-adjuvant porous microneedle (PSAPMN)...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69e07e242f7e8953b7cbf143https://doi.org/10.1039/d5bm01847a
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