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April 16, 2026Bulletin of the Russian Academy of Sciences Physics0 citations

Influenza A Virus Determination Using an Aptamer-Based Colorimetric Test System

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DTDaria TikhonovaEAE. V. AndreevTGT. S. Grishin

Key Points

  • The study aims to develop a method for detecting influenza A virus using an aptamer-based test system.
  • Immobilization of DNA aptamers on a porous polyethylene terephthalate substrate.
  • Use of gold nanoparticles to enhance detection.
  • Assembly of a ternary complex with aptamer-functionalized substances and the virus.
  • Successful preservation of recognition elements on the substrate.
  • The formation of a ternary complex was demonstrated.
  • Potential for creating effective aptamer-based test strips.

Abstract

A method for immobilizing DNA aptamers on the surface of a porous polyethylene terephthalate substrate and gold nanoparticles has been developed, preserving the functionality of the recognition elements. The possibility of assembling a ternary complex composed of aptamer-functionalized porous polymeric substrate, influenza A virus, and aptamer-functionalized gold nanoparticles is shown. These results can be used to create aptamer-based test strips.

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Cite This Study

Tikhonova et al. (2026) studied this question.

synapsesocial.com/papers/69e07e3b2f7e8953b7cbf423https://doi.org/10.1134/s106287382571517x
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