PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
April 16, 2026The Journal of Organic Chemistry0 citations

Base-Catalyzed One-Pot Synthesis of Indolizine-1-Carboxylates Tethered to Benzofurans

Base-Catalyzed One-Pot Synthesis of Indolizine-1-carboxylates Tethered to 2-Aroyl Benzofurans and Benzothiophenes

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJuyoung LeeSASooseong AhnKEKihyeon Eom

Discussion

Loading...

Member takes

Overview

A base-catalyzed synthesis produces new indolizine derivatives with potential applications in organic chemistry.

Key Points

  • The research aims to develop an efficient method for synthesizing indolizine-1-carboxylates that are chemically versatile and accessible.
  • Utilized a base-catalyzed one-pot reaction
  • Combined 2-pyridin-2-ylacetates, DMF-DMA, and 2-aroyl-benzofuran/benzothiophene-3-methyl bromides
  • Evaluated a range of substituents on reactants
  • Achieved gram-scale synthesis without chromatography
  • Diverse indolizine derivatives were obtained in moderate to good yields
  • The method tolerated a broad range of substituents
  • Postsynthetic Suzuki coupling led to complex indolizine-benzofuran structures

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69e07e582f7e8953b7cbf651https://doi.org/10.1021/acs.joc.6c00082
View Full Paper
Ask AI
Bookmark
Share