Engineering immunostimulatory nanocarriers: TLR7-agonist conjugated poly(β-amino ester) mRNA delivery systems

Puntos clave

• To improve the delivery of mRNA medicines using TLR7-agonist conjugated nanocarriers.
• Developed poly(β-amino ester) nanocarriers for mRNA delivery.
• Conjugated TLR7 agonist to enhance immunostimulatory effects.
• Evaluated cellular uptake and delivery efficiency of the nanocarriers.
• Demonstrated improved cellular association of mRNA compared to naked mRNA.
• Observed enhanced immune response in vitro due to TLR7 activation.
• Showed potential for novel vaccine applications.