A Multicenter Retrospective Observational Study on Steroid-Dependent or Refractory Idiopathic Pneumonia Syndrome After Hematopoietic Stem Cell Transplantation

Key Points

• This research aims to clarify the course and prognosis of steroid-dependent or refractory idiopathic pneumonia syndrome after hematopoietic stem cell transplantation.
• Multicenter retrospective observational study
• Enrollment of 29 cases showing steroid dependency or refractory symptoms
• Assessment based on treatment response after 3 days and 5 days post-treatment
• Overall survival rate at 56 days was 37.9% (95% CI 20.7%-57.7%)
• Overall survival rate at 100 days was 27.6% (95% CI 12.7%-47.2%)
• 24 out of 29 cases (82.8%) died by the end of the follow-up
• All patients requiring mechanical ventilation died
• High daily steroid dosage of 3.3±3.8mg/kg was noted

Abstract