What question did this study set out to answer?

To highlight the rare synchronous occurrence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the liver.

April 17, 2026Open Access

Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report

Key Points

To highlight the rare synchronous occurrence of hepatocellular carcinoma and intrahepatic cholangiocarcinoma in the liver.
Case report of a patient with synchronous tumors
Assessment of tumor locations and characteristics
Review of literature on double primary hepatic cancers
Identified two distinct tumors in different liver locations
Observed that this condition occurs in less than 0.8% of liver malignancies
Emphasized the need for further research into DPHC

Abstract

INTRODUCTION: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) are the most common and second most common primary liver cancers, respectively. In contrast, double primary hepatic cancer (DPHC), the synchronous occurrence of these two tumors in different locations of the liver, is an uncommon pathology, occurring in less than 0.8% of all liver malignancies.

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Discussion

Authors

Takahiro Yoshimura

Hironori Hayashi

Kazuki Kato

Journals

Surgical Case Reports

Actions

Institutions

Kanazawa University Hospital

Kouseiren Takaoka Hospital

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Synchronous Double Primary Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: A Case Report

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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