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April 17, 2026Asian Journal of Organic Chemistry0 citations

Phenanthroline‐Mediated, Metal‐ and Photocatalyst‐Free Visible‐Light Synthesis of Quinazolin‐4(3 H )‐ones From 2‐Amidoaryl Oxazolines for Rapid‐Readout System Applications

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WCWeiqiang ChenHLHao Long

Key Points

  • To develop a sustainable method for synthesizing quinazolin-4(3H)-ones from 2-amidoaryl oxazolines using visible light.
  • Metal- and photocatalyst-free synthesis
  • Utilization of phenanthroline as a promoter
  • Application of visible light in reactions
  • Simplified protocol under mild conditions
  • Synthesis of quinazolin-4(3H)-ones achieved without costly metals
  • Successful application in a rapid-readout system
  • Demonstrated operational simplicity and sustainability

Abstract

ABSTRACT A novel, metal‐ and photocatalyst‐free strategy has been developed for the visible‐light synthesis of quinazolin‐4(3H)‐ones from 2‐amidoaryl oxazolines, with phenanthroline serving as a crucial promoter. The strategy highlights the potential of using readily available organic molecules to construct complex heterocycles under mild conditions. This approach offers a sustainable and operationally simple protocol, avoiding the need for costly metals or specialized photoactive catalysts. Importantly, the resulting quinazolin‐4(3 H )‐ones have been successfully applied in a rapid‐readout system, demonstrating their utility for fast and convenient detection.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69e1ce895cdc762e9d8579a9https://doi.org/10.1002/ajoc.70388
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