Comparing Hemostatic Efficacy of Four-Factor Prothrombin Complex Concentrate with Andexanet Alfa in an Apixaban-Treated Polytrauma Male Porcine Model

Puntos clave

• The research aims to compare the hemostatic efficacy of four-factor prothrombin complex concentrate and andexanet alfa in a porcine model treated with apixaban.
• Conducted in a male polytrauma porcine model.
• Administered high-dose 4F-PCC and andexanet alfa for hemostatic assessment.
• Monitored factors II, VII, IX, and X levels and thrombin generation.
• Both treatments were fully effective for achieving survival and controlling bleeding.
• Andexanet alfa provided faster hemostasis compared to 4F-PCC.
• 4F-PCC demonstrated sustained restoration of coagulation factors and thrombin generation.