A picture of health: gene-expression maps of the human liver from living donors

Key Points

• The research aims to create a detailed gene-expression atlas of the human liver from living donors to understand its healthy function and potential disease adaptations.
• Assembled a high-resolution atlas using gene-expression profiling.
• Conducted spatial mapping of liver cells in samples from living donors.
• Analyzed gene expression patterns in different zones of the liver.
• Identified human-specific patterns of gene expression in healthy liver cells.
• Revealed adaptations in liver cells from individuals with steatosis.
• Provided a reference atlas for healthy liver function and disease understanding.

Abstract