What question did this study set out to answer?

The study examines compliance with treatment protocols for Wilms tumour in children, particularly in advanced stages.

April 17, 2026Open Access

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Key Points

The study examines compliance with treatment protocols for Wilms tumour in children, particularly in advanced stages.
Analyzed adherence to protocol recommendations in two consecutive studies.
Examined outcomes based on centre size and treatment protocols.
Conducted a review of central pathology for consistency in diagnoses.
Lower stage tumours showed high adherence to treatment protocols.
Advanced disease exhibited significant variation in adherence to guidelines.
No link was found between centre size and survival outcomes.

Abstract

Protocol guidelines are followed closely for lower stage tumours, but there is greater variation in advanced disease. Centre size showed no association with survival, emphasising the effectiveness of using a national treatment protocol, supported by central pathology review.

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