Fine-Tuned Large Language Models for Automated Radiology Impression Generation: A Multicenter Evaluation

Purpose To develop a fine-tuned large language model (Medical Imaging Report Assistant, MIRA) and evaluate its performance in generating radiology impressions from multicenter data with respect to accuracy, reporting efficiency, and clinical applicability. Materials and Methods A retrospective multicenter dataset comprising 1.87 million radiology reports (including CT, MRI, and digital radiography data) from 42 hospitals across 22 provinces in China (January 2019 to August 2024) was compiled. The dataset was used to fine-tune an LLM via a prompt-based strategy. The evaluation framework incorporated both automated and human evaluation metrics. Radiologists evaluated internal and external datasets and three open-source datasets to compare impressions generated by the fine-tuned LLM and GPT-4o. Twenty-four radiologists from six centers performed blinded comparisons of MIRA generated and reference impressions to assess interrater consistency and drafting efficiency. Data were analyzed using appropriate parametric/nonparametric tests and χ2 tests, with Holm-Bonferroni correction for multiple comparisons. Results The internal test set included data for 78,544 reports, median age, 52 years IQR, 35-65, 39,351 males) and the external test set included data for (27,471 reports, median age, 53 years IQR, 37-66, 13,955 males). Site/modality-aware prompting improved similarity (P n = 2,327) showed MIRA beat GPT-4o on both similarity and F1 score (P P < .001). Conclusion MIRA, a fine-tuned LLM using a prompt-based strategy, generated clinically aligned radiology impressions in multicenter settings, improving accuracy, efficiency, and reporting consistency. © The Authors 2026. Published by the Radiological Society of North America under a CC BY 4.0 license.