What question did this study set out to answer?

This research aims to identify the role of the SIRT7-HIF-1α pathway in keratinocyte function and psoriasis progression.

April 18, 2026Open Access

Sirtuin 7-mediated deacetylation of hypoxia-inducible factor 1-alpha facilitates glycolytic reprogramming and inflammation of keratinocytes in psoriasis

YLYixin LuoXijing Hospital XSXiaolei SuLudong University CZChen Bo Calvin ZhangHong Kong Polytechnic University

Puntos clave

This research aims to identify the role of the SIRT7-HIF-1α pathway in keratinocyte function and psoriasis progression.
Examined SIRT7-mediated deacetylation effects on HIF-1α in keratinocytes
Analyzed changes in keratinocyte metabolism and inflammation
Investigated the implications for psoriasis progression
SIRT7 promotes glycolytic reprogramming in keratinocytes
HIF-1α deacetylation was linked to increased inflammation
Findings suggest targeting SIRT7 could help manage psoriasis

Resumen

Our findings reveal a novel SIRT7-HIF-1α signaling pathway that regulates keratinocyte metabolism, proliferation, and inflammation, which is involved in promoting psoriasis progression. This finding identifies a potential therapeutic target for psoriasis management.

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