E3 Ubiquitin Ligase RNF10 Negatively Regulates Rbpjk Expression During Vascular Calcification in Chronic Kidney Disease

Key Points

• The study aims to investigate the role of RNF10 in regulating Rbpjk expression during vascular calcification in chronic kidney disease.
• Analyzed the effects of RNF10 depletion on Rbpjk expression
• Examined osteogenic differentiation in the context of vascular calcification
• Investigated the regulatory relationship between RNF10 and Rbpjk
• RNF10 depletion initiated Rbpjk-driven osteogenic differentiation
• RNF10 negatively regulates Rbpjk expression
• The RNF10-Rbpjk axis offers new insights for therapeutic strategies in vascular calcification

Abstract