What question did this study set out to answer?

To demonstrate the diagnostic value of dual tracer imaging in localizing tumours associated with tumour-induced osteomalacia.

April 18, 2026Open Access

Dual Tracer Imaging Resolving a Clinical Dilemma in Tumour-Induced Osteomalacia

YDYamini DharmashaktuAll India Institute of Medical Sciences NDNishikantAvinash DamleAll India Institute of Medical Sciences SKSachin Krishna Raj KAll India Institute of Medical Sciences

Key Points

To demonstrate the diagnostic value of dual tracer imaging in localizing tumours associated with tumour-induced osteomalacia.
Presented a case of a 32-year-old male with recurrent TIO symptoms.
Conducted positron emission tomography-computed tomography (PET-CT) scans for tumour localization.
Analyzed the imaging findings to improve diagnosis.
Successfully localized the mesenchymal tumour causing TIO.
Highlighted the role of fibroblast growth factor 23 in TIO diagnosis.
Enhanced understanding of targeted functional imaging benefits for TIO.

Abstract

Tumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome associated with mesenchymal tumours that secrete phosphaturic proteins, with most of the patients having elevated levels of fibroblast growth factor 23. Here, we present a case of a 32-year-old male who presented with recurrent symptoms of TIO and underwent positron emission tomography-computed tomography scans for localisation. This case highlights the diagnostic value of targeted functional imaging in challenging TIO localisation.

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