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April 18, 2026BiomedicinesOpen Access

The Paradoxical Role of Pyroptosis in Gastrointestinal Cancers: From Molecular Mechanisms to Therapeutic Horizons

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Authors

JTJohn K. Triantafillidis

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Overview

This review examines pyroptosis and its dual effects on gastrointestinal cancers, indicating its potential in therapy.

Key Points

  • The review aims to explore the molecular mechanisms of pyroptosis in gastrointestinal cancers and its therapeutic implications.
  • Reviewed the signaling pathways involved in pyroptosis in the gastrointestinal tract.
  • Analyzed the effects of pyroptosis on tumor progression and suppression.
  • Evaluated pharmacological and microbiome-based interventions that target pyroptosis.
  • Pyroptosis can suppress tumors through immune activation, contributing to immunogenic cell death.
  • Chronic inflammation from pyroptosis may facilitate tumor progression.
  • Emerging therapies focus on inducing pyroptosis as a part of immunotherapeutic strategies.

Cite This Study

John K. Triantafillidis (2026) studied this question.

synapsesocial.com/papers/69e320e740886becb654005dhttps://doi.org/10.3390/biomedicines14040911
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