Asian ethnicity is associated with shorter anti-resorptive exposure prior to atypical femur fracture (AFF): a Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) cohort study
Cohort study reveals Asian ethnicity linked to earlier atypical femur fracture onset, suggesting treatment adjustments.
Key Points
To explore the relationship between Asian ethnicity and the duration of anti-resorptive treatment before atypical femur fractures (AFFs).
Cohort study involving 166 patients with AFFs from the Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) registry.
Comparison of physical characteristics (height and weight) between Asian and non-Asian individuals with AFFs.
Assessment of prior trauma fracture history and response to teriparatide treatment.
Asian individuals had a lower average height (152.0 cm) compared to non-Asian peers (154.6 cm, p < 0.038).
Asian individuals weighed less (57.5 kg vs. 66.8 kg, p < 0.001) than their non-Asian counterparts.
Asian ethnicity was associated with a significantly higher likelihood of developing AFFs after ≤ 5 years of anti-resorptive treatment (OR 2.10, p = 0.034).
Southeast Asian ethnicity was linked to an even greater likelihood of earlier AFF development (OR 3.25, p = 0.002).