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Synapse
April 18, 2026Science

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Authors

JTJessica TollkühnSBS. Marc Breedlove

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Overview

Analysis reveals sex differences in gene expression in the brain, suggesting biological variation between genders.

Key Points

  • This research aims to explore how gene expression in the brain varies between men and women.
  • Genomic analysis of brain tissue samples
  • Comparison of gene expression profiles between genders
  • Identification of over 3000 differently expressed genes
  • Over 3000 genes show different levels of expression between men and women
  • Identified specific gene pathways related to sex differences
  • These findings suggest biological underpinnings for gender-related behaviors.

Cite This Study

Tollkühn et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb65403e4https://doi.org/10.1126/science.aeh0064
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex- and brain region-specific gene expression in Alzheimer's disease2026
  2. 2Sex effects on gene expression across the human cerebral cortex at cell type resolution2026 · 12 citations
  3. 3Integrated analysis of robust sex-biased gene signatures in human brain2023 · 28 citations
  4. 4Relationship between sex biases in gene expression and sex biases in autism and Alzheimer’s disease2024 · 12 citations
  5. 5A sex-stratified analysis of the genetic architecture of human brain anatomy2024 · 3 citations