What question did this study set out to answer?

To validate the Japanese Brief Repeatable Battery of Neuropsychological Tests and establish cognitive impairment thresholds for individuals with multiple sclerosis.

April 18, 2026Cognitive and Behavioral Neurology

The Japanese Version of the Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis: A Preliminary Validation

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Authors

SAShun AkaikeHokkaido University NMNobuhiro MifuneKochi University of Technology IYIchiro YabeHokkaido University

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Overview

This validation study demonstrates reliable cognitive assessment in multiple sclerosis, suggesting clinical utility for the Japanese Brief Repeatable Battery.

Key Points

To validate the Japanese Brief Repeatable Battery of Neuropsychological Tests and establish cognitive impairment thresholds for individuals with multiple sclerosis.
Evaluated internal consistency using Cronbach’s α
Conducted receiver operating characteristic analyses for discriminative ability
Used Bayesian logistic regression and frequentist logistic regression for sensitivity analysis
Derived classification thresholds via the Youden Index
Assessed parallel-form reliability comparing two BRB-N versions
Japanese BRB-N showed acceptable internal consistency (Cronbach’s α = 0.78)
Achieved an area under the curve of ≥0.70 in cognitive tests
Paced Auditory Serial Addition Test scores were notably high (0.92)
Eight out of 13 measures indicated strong effects with significant probabilities
No significant differences found between parallel forms A and B

Cite This Study

Akaike et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb654043b https://doi.org/10.1097/wnn.0000000000000422

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April 18, 2026Cognitive and Behavioral Neurology

The Japanese Version of the Brief Repeatable Battery of Neuropsychological Tests in Multiple Sclerosis: A Preliminary Validation

View Full Paper

Ask AI

Bookmark

Authors

SAShun AkaikeHokkaido University NMNobuhiro MifuneKochi University of Technology IYIchiro YabeHokkaido University

Discussion

Member takes

Overview

This validation study demonstrates reliable cognitive assessment in multiple sclerosis, suggesting clinical utility for the Japanese Brief Repeatable Battery.

Key Points

To validate the Japanese Brief Repeatable Battery of Neuropsychological Tests and establish cognitive impairment thresholds for individuals with multiple sclerosis.
Evaluated internal consistency using Cronbach’s α
Conducted receiver operating characteristic analyses for discriminative ability
Used Bayesian logistic regression and frequentist logistic regression for sensitivity analysis
Derived classification thresholds via the Youden Index
Assessed parallel-form reliability comparing two BRB-N versions
Japanese BRB-N showed acceptable internal consistency (Cronbach’s α = 0.78)
Achieved an area under the curve of ≥0.70 in cognitive tests
Paced Auditory Serial Addition Test scores were notably high (0.92)
Eight out of 13 measures indicated strong effects with significant probabilities
No significant differences found between parallel forms A and B

Cite This Study

Akaike et al. (2026) studied this question.

synapsesocial.com/papers/69e3211640886becb654043b https://doi.org/10.1097/wnn.0000000000000422

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