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April 18, 2026Neuroendocrinology0 citations

Stress-Induced Activation of Orexin-A Neurons in Male and Female Rats Across Development

Stress-induced activation of orexin-A neurons in the lateral hypothalamus is similar in prepubertal and adult male and female rats despite age-dependent differences in hormonal stress reactivity

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Authors

CSChelsea A. SeidelSCSofia CruzJOJuliet Dayana Pérez Ortiz

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Overview

Research reveals similar activation of orexin-A neurons in males and females, despite hormonal stress reactivity differences during development.

Key Points

  • This research aims to investigate how stress affects orexin-A neurons in prepubertal and adult rats and to explore hormonal stress responses across development.
  • Examined hormonal stress responses in prepubertal and adult rats
  • Counted activated orexin-A neurons by co-labeling with c-Fos
  • Quantified immunoreactive orexin-A neurons in different developmental stages of both sexes
  • Prolonged stress-induced hormonal responses in prepubertal males and females compared to adults
  • No developmental differences in the number of orexin-A neurons or their activation levels across sexes
  • Orexin-A neurons show consistent sensitivity to stressors prior to puberty

Cite This Study

Seidel et al. (2026) studied this question.

synapsesocial.com/papers/69e3215140886becb65407d3https://doi.org/10.1159/000552033
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