Synthesis of 4-quinolones via a palladium-catalyzed carbonylative cyclization of o-iodoanilines and alkynes

Key Points

• The aim is to develop an efficient method for the synthesis of 4-quinolones using palladium catalysis.
• Utilized a palladium-catalyzed reaction
• Engaged o-iodoanilines and alkynes
• Conducted carbonylative cyclization process
• Successfully synthesized 4-quinolones
• Achieved step-economical synthesis
• Displayed broad spectrum of biological activities

Abstract