Retrospective analysis shows BMPC infiltration predicts treatment response and survival in AL amyloidosis, implying its use in clinical decision-making.
Key Points
This study evaluates the prognostic significance of bone marrow plasma cell infiltration at diagnosis in AL amyloidosis patients.
Retrospective analysis of 116 AL amyloidosis patients diagnosed between 2010 and 2024.
Patients divided into two groups based on BMPC infiltration rate: ≤10% and >10%.
Evaluated clinical features, organ involvement, treatment responses, and survival outcomes using statistical methods.
Patients with BMPC >10% had higher levels of involved free light chains and worse disease stage.
Median overall survival was 56 months for BMPC ≤10% and 16 months for BMPC >10%.
BMPC infiltration >10% was identified as an independent predictor of early mortality and worse overall survival.