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April 19, 2026Journal of Advanced ResearchOpen Access

SFRP2 aggravates diabetic kidney disease by repressing the renal protective CH25H/25-hydroxycholesterol axis in mesangial cells

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Authors

DLDan LvZLZiyue LinJYJ Yang

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Overview

Research demonstrates SFRP2's role in worsening kidney disease in diabetes, suggesting new treatment avenues.

Key Points

  • The study aims to investigate how SFRP2 influences the progression of diabetic kidney disease (DKD) and its associated mechanisms.
  • Analyzed the role of SFRP2 in mesangial cells from DKD models.
  • Examined cholesterol accumulation linked to SFRP2 activity.
  • Assessed the potential of targeting CH25H/25-HC for therapeutic strategies.
  • SFRP2 was found to increase renal cholesterol levels in diabetic models.
  • The CN/ATF3/HDAC1/CH25H signaling pathway was identified as a key mechanism.
  • Targeting 25-HC restoration or SREBP2 inhibition shows potential benefits for DKD treatment.

Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/69e470a4010ef96374d8d837https://doi.org/10.1016/j.jare.2026.04.043
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Also Consider

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  1. 1Exosome-based <i>Sfrp2</i> inhibition in mesangial cells alleviates osteoporosis and promotes osteointegration in diabetic kidney disease2025
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  3. 3High-dose SFRP2 attenuates fibrosis and promotes angiogenesis via Wnt signaling modulation in diabetic erectile dysfunction2026
  4. 4Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction2026
  5. 5SRPK1 is a significant factor in driving the progression of diabetic kidney fibrosis2025 · 1 citations