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April 19, 2026PLoS ONEOpen Access

Extensive intraoperative peritoneal lavage (EIPL) for gastric cancer with positive peritoneal lavage and/or stamp cytology: An exploratory phase II study

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Authors

GTGen TsujioMYMasakazu YashiroYMYuichiro Miki

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Overview

Exploratory Phase II study investigates the impact of extensive lavage on relapse-free survival in gastric cancer patients, suggesting potential benefits.

Key Points

  • This exploratory Phase II study evaluates the impact of extensive intraoperative peritoneal lavage on relapse-free survival in patients with gastric cancer and positive cytology.
  • Single arm, multi-institutional, exploratory phase 2 trial
  • Included patients with positive peritoneal and/or stamp cytology
  • Primary endpoint: relapse-free survival, secondary endpoints: overall survival, recurrence sites, adverse events
  • 13 patients enrolled from 2017 to 2021
  • Median 3-year relapse-free survival was 14.5 months
  • Median 3-year peritoneal relapse-free survival rate was 83% in CY0 and stamp+ cases and 0% in CY1 cases
  • Statistically significant difference with log-rank p=0.015

Cite This Study

Tsujio et al. (2026) studied this question.

synapsesocial.com/papers/69e471ef010ef96374d8e224https://doi.org/10.1371/journal.pone.0347742
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