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April 19, 2026Annals of Laboratory Medicine0 citationsOpen Access

Caspase-1 Activation in Monocyte Subsets Is Associated with Monocyte Distribution Width

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YLYing LiuFPFei PeiDWDong Wang

Key Points

  • This research investigates the relationship between caspase-1 activation in monocyte subsets and monocyte distribution width (MDW).
  • Evaluated monocyte subset proportions and caspase-1 activation levels in subjects.
  • Analyzed correlations between these parameters and MDW.
  • Focused on non-classical monocyte activity in the context of sepsis.
  • Found elevated MDW correlates with altered monocyte subset proportions.
  • Observed enhanced caspase-1 activation linked to MDW, especially in non-classical monocytes.
  • Suggests a clinically relevant link between MDW and sepsis-associated monocyte dysfunction.

Abstract

Elevated MDW correlates with altered monocyte subset proportions and enhanced in vivo caspase-1 activation, with a particularly strong association with non-classical monocyte caspase-1 activity. Given that non-classical monocyte caspase-1 activity is markedly increased in patients with sepsis, our results suggest a potential clinically relevant association linking MDW to sepsis-associated monocyte dysfunction, which may inform the interpretation of MDW in clinical practice.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69e471ef010ef96374d8e238https://doi.org/10.3343/alm.2025.0643
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