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April 19, 2026Nature CommunicationsOpen Access

Dysfunction of the episodic memory network in the Alzheimer’s disease cascade

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Authors

RLRené LattmannNVNiklas VockertJBJosé Bernal

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Overview

This research assesses episodic memory dysfunction's impact on Alzheimer's disease biomarkers and cognition, indicating significant implications for treatment strategies.

Key Points

  • The study aims to understand how episodic memory network dysfunction relates to Alzheimer’s disease progression and cognitive decline.
  • Analyzed longitudinal fMRI data from over 1000 individuals in the DZNE DELCODE study.
  • Investigated activation and deactivation patterns of the episodic memory network.
  • Conducted voxel-wise analyses to assess neurodegeneration and cognitive decline.
  • Evaluated disease progression scores using a disease progression model.
  • Identified widespread loss of activation and deactivation within the episodic memory network.
  • Noted nonlinear trajectories for loss of deactivation associated with amyloid and tau positivity.
  • Observed that the deactivation loss trajectory visually preceded cognitive decline.
  • Found that deactivation's relationship to cognitive decline was partially independent of neurodegeneration.

Cite This Study

Lattmann et al. (2026) studied this question.

synapsesocial.com/papers/69e471ef010ef96374d8e251https://doi.org/10.1038/s41467-026-71831-z
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Also Consider

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