PRS-guided pharmacotherapy represents a transformative strategy for personalized combination treatment in complex diseases by integrating phenotypic response data with computational optimization to improve therapeutic precision. However, broader clinical adoption will require rigorous external validation, integration of multimodal patient data, improved interpretability of AI-assisted models, and supportive regulatory frameworks. With these advances, PRS-based approaches may become an important component of next-generation precision pharmacotherapy.
Khalil et al. (Fri,) studied this question.