Systemic and local antibiotics in the management of peri‐implantitis: A systematic review and network meta‐analysis

Key Points

• The aim is to determine the effectiveness of systemic and local antibiotics in managing peri-implantitis.
• Conducted a systematic review and network meta-analysis of antibiotic treatments.
• Evaluated various treatment combinations including metronidazole and amoxicillin.
• Analyzed clinical and microbiological outcomes related to antibiotic use.
• Metronidazole with non-surgical treatment was identified as highly effective.
• Combined use of amoxicillin and metronidazole in open flap debridement showed improved results.
• Local antibiotic applications were less effective than systemic treatments in improving clinical parameters.

Abstract