What question did this study set out to answer?

The research aims to evaluate the relationship between BNP levels and blood pressure in patients with high hypertension in the ED.

April 19, 2026Cureus0 citationsOpen Access

Assessment of Brain Natriuretic Peptide Levels in Patients Presenting to the Emergency Department With High Blood Pressure

Q: What is the clinical evidence from this study?

Study design: Observational. Population: High blood pressure (n=204). Intervention: No regular antihypertensive treatment vs. Regular antihypertensive treatment. Primary outcome: Median plasma BNP level (pg/mL) (p=<0.001).

CDCihangir Doruk

Resultado clave

Patients not receiving regular antihypertensive treatment had significantly higher median plasma BNP levels compared to treated patients (259.5 vs 67.7 pg/mL).

Puntos clave

The research aims to evaluate the relationship between BNP levels and blood pressure in patients with high hypertension in the ED.
Conducted a single-center, prospective study with 204 adults exhibiting high blood pressure.
Categorized patients based on antihypertensive medication status.
Measured plasma BNP levels using a chemiluminescent immunoassay.
Examined correlations between BNP levels and blood pressure values.
Median BNP level was 79.4 pg/mL, with a range from 9.1 to 3500 pg/mL.
Moderate correlation found between BNP and diastolic blood pressure (r = 0.523; p < 0.001).
BNP levels were significantly higher in untreated patients than those receiving treatment (median: 259.5 vs 67.7 pg/mL, p < 0.001).
Diastolic blood pressure was the only independent predictor of BNP levels.

Diseño del estudio

Tipo

Observational (n=204)

Multicéntrico

PICO estructurado

Población

204 adults (aged ≥18 years) presenting to the emergency department with systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg, mean age 58.4, 74% female, in Turkey. Excluded: known or documented congestive heart failure, acute or chronic renal failure, acute coronary syndrome, significant infection, systemic inflammatory disease, or pregnancy.

Resultado

Brain natriuretic peptide (BNP) levels and their relationship with systolic and diastolic blood pressures according to antihypertensive treatment statussurrogate

In patients presenting to the emergency department with high blood pressure, BNP levels correlate with diastolic blood pressure and are significantly higher in those not receiving regular antihypertensive treatment, suggesting it may reflect acute hemodynamic stress.

Resultado numérico

Tasa de eventos absoluta: 259.5% vs 67.7%

valor p: p=<0.001

Limitaciones

Single-center design
Lack of echocardiographic data
Absence of detailed information regarding the duration of hypertension
Unavailability of renal function and body mass index data
Data collected in 2012
Target organ damage parameters and clinical outcomes not evaluated
Patients not stratified according to clinical categories such as hypertensive urgency or emergency

Resumen

Objective: Hypertension is one of the leading causes of cardiovascular morbidity and mortality worldwide. Although patients presenting to emergency departments (EDs) with high blood pressure (BP) are frequently seen, it is difficult to distinguish patients with true hemodynamic or cardiac stress. Brain natriuretic peptide (BNP), secreted in response to ventricular wall strain, may serve as a useful biomarker. This study was conducted to evaluate BNP levels in patients presenting to the ED with high BP and to examine their relationship with systolic and diastolic pressures according to the antihypertensive treatment status. Methods: This single-center, prospective study included 204 adults who presented with systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg between July 2012 and December 2012. Patients with heart or kidney failure, acute coronary syndrome, or pregnancy were excluded from the study. Plasma BNP was measured using a chemiluminescent immunoassay. Participants were grouped according to antihypertensive medication use, and BNP levels were compared with BP values. Results: The median BNP level was 79.4 pg/mL (range: 9.1-3500). BNP showed a moderate correlation with diastolic blood pressure (DBP) (r = 0.523; p 0.05). BNP levels were higher in untreated patients than in treated patients (median: 259.5 and 67.7 pg/mL, p < 0.001). No significant difference was observed between drug classes. DBP was the only independent predictor of BNP. Conclusion: BNP levels were significantly higher in patients not receiving regular antihypertensive treatment, particularly in those with higher DBP. BNP measurement in selected ED cases may provide additional information regarding hemodynamic stress; however, larger multicenter studies are needed to clarify its clinical utility and determine whether practical thresholds can be defined.

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Cite This Study

Cihangir Doruk (Fri,) conducted a observational in High blood pressure (n=204). No regular antihypertensive treatment vs. Regular antihypertensive treatment was evaluated on Median plasma BNP level (pg/mL) (p=<0.001). Patients not receiving regular antihypertensive treatment had significantly higher median plasma BNP levels compared to treated patients (259.5 vs 67.7 pg/mL).

synapsesocial.com/papers/69e472d8010ef96374d8ec1b https://doi.org/https://doi.org/10.7759/cureus.107222

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