Mechanistic perspectives on antimalarial agents: from FDA-approved drugs to next-generation candidates

Key Points

• This research aims to categorize antimalarial agents based on their mechanisms of action.
• Reviewed various classes of antimalarial drugs
• Organized drugs into categories based on mechanisms such as heme and mitochondrial inhibitors
• Highlighted both FDA-approved and next-generation drug candidates
• Identified key drug classes and their specific mechanisms
• Showcased next-generation candidates targeting established resistance pathways
• Provided insights into potential future directions for antimalarial development