What question did this study set out to answer?

To investigate the relationship between EMMPRIN levels in uterine ligaments and the occurrence of pelvic organ prolapse (POP).

April 19, 2026Urogynecology0 citations

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The Role of EMMPRIN Levels in Uterine Ligaments in Pelvic Organ Prolapse

AYAyşe Ceren Yildiz ZAZelal Aydin KTKübra Keskin Toptas

Key Points

To investigate the relationship between EMMPRIN levels in uterine ligaments and the occurrence of pelvic organ prolapse (POP).
Analysis of EMMPRIN levels in uterosacral ligament, cardinal ligament, and ligamentum rotundum.
Comparison between patients with pelvic organ prolapse and healthy subjects.
EMMPRIN levels were significantly lower in patients with pelvic organ prolapse.
Deficiency of EMMPRIN may contribute to the development of pelvic organ prolapse.

Abstract

EMMPRIN levels in the uterosacral ligament, cardinal ligament and ligamentum rotundum were significantly lower in patients with POP. EMMPRIN deficiency may be one mechanism underlying the development of POP, but multicenter studies with larger patient numbers are needed.

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The Role of EMMPRIN Levels in Uterine Ligaments in Pelvic Organ Prolapse

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