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April 19, 2026Pathogens0 citationsOpen Access

Assessment of IL-6 and IL-8 Biomarkers for Predicting Dengue Severity Across Serotypes

Assessment of IL-6 and IL-8 Levels and Other Bio Markers in Predicting Dengue Severity Across Serotypes

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Authors

KSKumar SivasubramanianRBRudrappan Raj BharathLVLeela Kakithakara Vajravelu

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Overview

This cohort study evaluates IL-6 and IL-8 levels to predict dengue severity, indicating potential biomarkers for timely management.

Key Points

  • The study aims to assess the predictive value of IL-6 and IL-8 levels in determining dengue severity across different serotypes.
  • Conducted as a prospective cohort study at a tertiary care hospital in southern India.
  • Included 69 patients with dengue warning signs, divided into severe (25) and non-severe (44) groups.
  • Analyzed serum samples for IL-6 and IL-8 levels on Days 1, 4, and 8.
  • Categorized patients based on dengue serotype and clinical findings.
  • IL-6 and IL-8 levels were significantly higher in severe dengue patients compared to non-severe patients on Days 1 and 4.
  • Elevated IL-8 levels correlated with longer hospital stays, suggesting its role as a disease progression predictor.
  • Secondary dengue infections were more prevalent in severe cases, with 88% being IgG positive.
  • Platelet transfusions were linked to longer hospital stays among patients.

Cite This Study

Sivasubramanian et al. (2026) studied this question.

synapsesocial.com/papers/69e4739a010ef96374d8f5b7https://doi.org/10.3390/pathogens15040434
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