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April 19, 2026Bioactive MaterialsOpen Access

Emerging engineering strategies in bone organoids: From biomimetic scaffolds to dynamic microenvironmental stimulation

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Authors

JHJiamian HanHGHongcheng GuZGZhongze Gu

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Overview

This review explores engineering strategies to enhance bone organoids for disease modeling and personalized medicine.

Key Points

  • To review advanced engineering strategies that address the challenges in creating functional bone organoids.
  • Critically examine biomimetic scaffolds and dynamic mechanical microenvironments.
  • Assess the integration of 3D bioprinting and microfluidic organ-on-a-chip systems.
  • Discuss the role of artificial intelligence in bone organoid development.
  • Engineering strategies are essential for constructing structural bone organoids.
  • Biomimetic scaffolds can guide cell fate effectively.
  • Stimuli-responsive materials enable enhanced mechanical environments for bone organoids.
  • Integrated platforms facilitate better vascularization and improve disease modeling.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69e473bd010ef96374d8f8b1https://doi.org/10.1016/j.bioactmat.2026.04.008
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